CORDIS Project
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This research aims to develop new synthetic methods for bioisosteres, which can improve drug properties and expand intellectual property options. By exploring innovative reactions, it seeks to create complex molecules that enhance the pharmaceutical industry's ability to design effective medications.
The pharmaceutical industry is increasingly seeking new tactics for the structural modification of drug candidates to avoid metabolic susceptibility, or to improve pharmacokinetic properties.
Analogues called 'bioisosteres', which mimic the dimensions and substituent directionality of problematic structural motifs, but which are not themselves subject to the same pharmacological issues, offer one solution.
Often based on scaffolds not found in ‘typical’ drug candidates, bioisosteres can addition…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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