CORDIS Project
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This project investigates the mechanisms of B-cell receptor engagement in chronic lymphocytic leukemia (CLL) to understand its role in disease progression. By employing machine learning, the project aims to identify specific biological features linked to CLL aggressiveness and treatment response, potentially leading to…
B-cell chronic lymphocytic leukemia (CLL), the most prevalent leukemia among adult Caucasians, is a disease characterized by the clonal expansion of B lymphocytes expressing CD5.
The B-cell receptor (BCR) plays a critical role in CLL development and progression as indicated by the efficacy of drugs blocking BCR signaling.
However, the mechanism(s) underneath BCR responsiveness are not well-defined and CLL remains incurable.
In the classical view, an interaction between BCR and extrinsic antigen…
UNIVERSITA DEGLI STUDI DI GENOVA
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