CORDIS Project
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This project investigates the sinoatrial node's function in heart rhythm regulation, focusing on intrinsic and extrinsic factors affecting pacemaker cells. It aims to understand the relationship between SAN dysfunction and atrial fibrillation using advanced human cell models.
The pacemaker cells of the sinoatrial node (SAN) trigger three billion heartbeats in an average human life span.
At the start of each beat, the SAN must generate enough current to drive the surrounding atrial tissue, which contains 10,000 times as many cells as the SAN itself.
This extraordinary biological feat is a result of intrinsic features such as SAN tissue architecture.
In addition, SAN function is modulated by extrinsic inputs from the autonomic nervous system, which adjusts the pace fro…
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