CORDIS Project
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This project investigates the potential of beauveriolides, a new class of fungal metabolites, as oral inhibitors of acyl-coenzyme A: cholesterol acyltransferase. By targeting cholesterol levels, the project aims to reduce the production and secretion of amyloid β-peptide, a key factor in Alzheimer's disease pathology.
The pathogenic event common to all forms of Alzheimer’s disease (AD) is the abnormal accumulation of the amyloid β-peptide (Aβ) in specific regions of the brain.
This accumulation of Aβ is considered a key pathological event in AD and is the basis of the so-called amyloid hypothesis of the disease.
Therefore, therapeutic approaches that reduce the accumulation of Aβ are currently being sought.
It has been shown definitively that the generation and clearance of Aβ in the brain is regulated by cho…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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