CORDIS Project
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This project focuses on understanding protein synthesis and quality control in the Endoplasmic Reticulum using advanced imaging techniques. By employing cryo-electron tomography, it aims to reveal the structural details of protein translocation and degradation processes, contributing to insights into diseases related t…
The Endoplasmic Reticulum (ER) membrane in all eukaryotic cells has an intricate protein network that facilitates protein biogene-sis and homeostasis.
The molecular complexity and sophisticated regulation of this machinery favours study-ing it in its native microenvironment by novel approaches.
Cryo-electron tomography (CET) allows 3D im-aging of membrane-associated complexes in their native surrounding.
Computational analysis of many sub-tomograms depicting the same type of macromolecule, a tec…
UNIVERSITEIT UTRECHT
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