CORDIS Project
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This project investigates the role of TElomeric Repeat containing RNA (TERRA) in maintaining telomere structure and function in mammalian cells and yeast. It aims to characterize TERRA's molecular functions, identify its promoter regions, and analyze its physiological regulators through various biological techniques.
Telomeres are heterochromatic nucleoprotein complexes located at the end of linear eukaryotic chromosomes.
Contrarily to a longstanding dogma, we have recently demonstrated that mammalian telomeres are transcribed into TElomeric Repeat containing RNA (TERRA) molecules. TERRA transcripts contain telomeric RNA repeats and are produced at least in part by DNA-dependent RNA polymerase II-mediated transcription of telomeric DNA. TERRA molecules form discrete nuclear foci that co-localize with telomer…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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