CORDIS Project
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The Bio-fluorine project aims to incorporate fluorine into natural products, specifically terpenoids, using biosynthetic enzymes. This research seeks to create new molecular structures that combine the benefits of synthetic and biological compounds for therapeutic applications.
Fluorine offers unique properties that are invaluable in molecular design and discovery.
Its importance is evidenced by theoverrepresentation of fluorine among synthetic small molecule therapeutics.
However, unlike synthetic chemists, nature rarely uses fluorine as part of its design tools to construct bioactive molecules.
To introduce fluorine into complex scaffolds such as natural products would offer enormous potential for accessing new structural space that combine beneficial features of bio…
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