CORDIS Project
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This project focuses on creating biocompatible nanoparticles to deliver small interfering RNA to activated T cells, aiming to reduce inflammation in chronic diseases like asthma. By targeting the GATA-3 transcription factor, the project seeks to prevent harmful immune responses without affecting naive T cells.
The aim of this proposal is to engineer biocompatible nanoparticles that deliver short interfering RNA (siRNA) to activated T cells (ATCs) for the downregulation of the Type 2 T helper cell (Th2) transcription factor GATA-3.
By downregulating GATA-3 with siRNA, which regulates the secretion of proinflammatory cytokines in chronic inflammatory diseases such as asthma, the activation of their downstream inflammatory cascades can be prevented.
However, T cells are hard-to-transfect cells which are…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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