CORDIS Project
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This project focuses on developing safer and more sustainable methods for producing isonitriles using biocatalysts derived from specific enzymes. By optimizing and engineering these enzymes, the project aims to enhance their efficiency and selectivity for industrial applications in various chemical fields.
Isonitriles are valuable organic molecules endowed with unique reactivity features, which find wide applications in a variety of chemical fields, from material sciences to chemical biology, organic, and medicinal chemistry.
Current methods to prepare isonitriles suffer from major drawbacks in terms of safety and sustainability, as they rely on the use of large amounts of highly toxic chemicals (e.g., COCl2, POCl3, TMSCN), which make their synthesis hazardous and wasteful, especially for industri…
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