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BioLure proposes a novel method for quantifying the intracellular delivery of biomolecules using a bioorthogonal luminescent reaction. This approach aims to enhance the understanding of endosomal escape and improve the development of non-viral delivery systems for therapeutic applications.
Intracellular delivery of membrane-impermeable biomacromolecules is essential for a broad spectrum of life sciences, ranging from fundamental biological studies to applied biomedical and pharmaceutical sciences.
Despite the great efforts in developing new intracellular delivery nanocarriers in the recent 20 years, simple, high-throughput, and accurate intracellular delivery quantification in live cells is still technically challenging.
In BioLure, I propose an unconventional approach to quantify…
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