CORDIS Project
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The project develops a bio-inspired, stent-less tissue-engineered mitral valve (BIOMITRAL) that mimics the natural structure and function of the heart valve. It aims to improve valve performance and adaptability for patients by incorporating engineered leaflets and chordal apparatus, addressing limitations of current p…
Tissue Engineered Heart Valves (TEHVs) can restore function in the pulmonary and aortic positions and have shown capacity for tissue regeneration and growth in pre-clinical models.
Yet, this concept has not been extended to the Mitral Valve (MV), whose pathologies affect >25% of the valve disease patients in Europe.
In this proposal, we introduce a bio-inspired design methodology and bioprocessing technology to engineer
BIOMITRAL: a polymeric, stent-less, tissue engineered MV that recapitulates…
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