CORDIS Project
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This research aims to develop a biomimetic system to study the nuclear pore complex, which regulates transport in eukaryotic cells. By using solid-state nanopore technology, it seeks to investigate the mechanisms of transport and selectivity of macromolecules.
Compartmentalization of the eukaryotic genome into a nucleus necessitates nuclear import and export to achieve basic cellular processes.
The nuclear pore complex (NPC) is a large (60 - 125 MDa) macromolecular structure in eukaryotic cells, where it spans the nuclear membrane and serves as the gatekeeper of nucleocytoplasmic transport.
While water, ions, and small molecules can freely diffuse through the NPC, macromolecules larger than 25 - 40 kDa cannot pass the NPC’s permeability barrier unless…
TECHNISCHE UNIVERSITEIT DELFT
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