CORDIS Project
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This project investigates liquid-liquid phase separation (LLPS) in biochemical processes, focusing on the interactions of proteins at different phases. Using advanced biophysical techniques, it aims to understand the mechanisms of phase separation and their implications for cancer treatment through targeted drug design…
Liquid-liquid phase separation (LLPS) is central to compartmentalisation of biochemical processes and allows co-localisation of a whole biological machine and its substrates at high local concentrations.
This often dynamic and reversible assembly is formed by multivalent interactions between several biomolecules, and some instances involve low complexity sequences that have been linked to amyloid fibre formation.
While the biophysical understanding of this phenomenon has recently been of high in…
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