CORDIS Project
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This research investigates the biophysical mechanisms that regulate T cell receptor activation by analyzing the spatial arrangement of signaling proteins and membrane lipids. It employs advanced microscopy techniques to understand protein clustering and its impact on immune responses.
The overall aim of this project is to identify key biophysical mechanisms that control the spatial arrangement of signalling proteins and membrane lipids in the regulation of T cell receptor (TCR) activation.
During an immune response, T cells are activated in response to antigenic peptides in a process that requires the formation of multi-molecular signalling complexes.
It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein LAT) are not randomly distri…
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