CORDIS Project
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This project focuses on developing an implantable hydrogel for cancer treatment that uses biorthogonal chemistry to activate drugs directly at the tumor site. The goal is to enhance immunotherapy outcomes by releasing a chemotherapeutic agent and an immunostimulant, promoting localized cancer cell death and immune resp…
In this fellowship I will leverage the recent advances in biorthogonal chemistry to develop an implantable catalytic hydrogel for chemoimmunotherapy through transition metal-mediated biorthogonal drug uncaging.
The past decade saw incredible advances in the field of cancer immunotherapies, with immune checkpoint blockade therapies and chimeric antigen receptor-T cell therapies demonstrating clinical efficacy.
However, issues still exist, as life-threatening side effects and limited patient respo…
KAROLINSKA INSTITUTET
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