CORDIS Project
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This project aims to develop new inhibitors for KPC-2, a key enzyme responsible for antibiotic resistance, using a novel method called kinetic-guided target synthesis. By creating boronic acid-based inhibitors, the project seeks to restore the effectiveness of beta-lactam antibiotics against resistant bacterial strains…
Herein, kinetic-guided target synthesis (KTGS) will be used to discover novel boronic acids inhibitors of KPC-2, a clinically relevant serine beta-lactamase, with the aim to tackle antimicrobial resistance (AMR) and restore beta-lactams antibiotic activity.
Boronic acids transition state inhibitors (BATSIs) have been extensively employed to inhibit beta-lactamases, a class of bacterial enzymes responsible for the most widespread mechanism of AMR against beta-lactam antibiotics.
However, the stru…
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
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United States, Cleveland Ohio
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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