CORDIS Project
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This project focuses on understanding the mechanisms of DNA double-strand break repair, particularly through the process of homologous recombination. It aims to elucidate the role of the BTRR complex in resolving Holliday junctions, which is crucial for preventing cancer.
Our genetic material is continually subjected to damage and efficient repair is needed for cancer avoidance. DNA double-strand breaks are cytotoxic and are repaired either by Non Homologous End-Joining or Homologous Recombination (HR). HR provides an important function in DNA repair, where it serves the dual purpose of mending broken chromosomes and recovering sequence information that might be lost at sites of DNA breaks.
The recombination process is initiated by exchange of strands between tw…
THE FRANCIS CRICK INSTITUTE LIMITED
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