CORDIS Project
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This project investigates the genomic organization of bacteria with multiple chromosomes, focusing on Vibrio cholera. It aims to understand how different chromosome structures influence gene expression and genetic integration, using advanced genomic engineering and RNA sequencing techniques.
Bacteria with Multiple-Chromosomes (BMC) are relatively frequent.
This project was designed to understand the advantages of such a genomic organization.
Based on observations from comparative genomics these could be: shorter generation time by providing additionalorigins of replication, a differential chromosome copy number regulation that changes relatives gene doses of the unlinked gene sets and physical separation of the “core genome” and the “flexible genome” genes.
This project will focus p…
INSTITUT PASTEUR
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