CORDIS Project
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This project investigates the role of bone marrow-derived cells in establishing the pre-metastatic niche for breast cancer. By analyzing cellular and molecular changes in distant organs, it aims to identify specific cell populations that facilitate metastasis, ultimately seeking to develop new strategies for prevention…
Breast cancer metastasis is a foreboding and prevalent disease for women around the world.
Over 90% of breast cancer deaths are caused by metastatic disease emphasizing the urgency for more research in this area.
While experimental evidence indicates that tumor cells must acquire specific genetic mutations to disseminate and colonize distant organs, these genetic alterations are not sufficient for successful metastasis formation.
The microenvironment of metastatic organs must also be pre-conditi…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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