CORDIS Project
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This project focuses on understanding the immune response to malaria by studying memory B cells and their antibodies. It aims to identify features that contribute to protective immunity, which could inform future vaccine development against Plasmodium falciparum.
Malaria is one of the leading life-threatening diseases with a reported 627,000 deaths and 241 million infections in 2020, mostly in low-income countries.
Despite the advances gained by control measures, malaria incidence by Plasmodium falciparum (Pf) has plateaued in the last decade.
Intervention through vaccines and antibody therapy shows promising results, yet long-lasting protective immunity remains unattainable.
Anti-malaria memory B cells comprise transcriptionally distinct sub-populations…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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