CORDIS Project
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This project investigates the role of autophagy in skeletal development and disorders, focusing on the influence of the FGF18 growth factor on chondrocyte cells. It aims to uncover molecular mechanisms that could lead to new treatments for skeletal diseases.
Autophagy is a fundamental cellular catabolic process deputed to the degradation and recycling of a variety of intracellular materials.
Autophagy plays a significant role in multiple human physio-pathological processes and is now emerging as a critical regulator of skeletal development and homeostasis.
We have discovered that during postnatal development in mice, the growth factor FGF18 induces autophagy in the chondrocyte cells of the growth plate to regulate the secretion of type II collagen,…
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