CORDIS Project
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This project focuses on developing a new approach to treat KRAS-mutated cancers using targeted protein degradation combined with bioorthogonal strategies. By utilizing small, drug-like fragments to create effective therapeutic agents, it aims to overcome limitations of existing treatments and enhance cancer therapy.
I propose an ambitious multidisciplinary strategy to address the challenge of targeting KRAS-mutated cancers through the combination of a novel bioorthogonal strategy to assemble bioactive agents and ‘targeted protein degradation’ (TPD). TPD is an innovative strategy to degrade targeted proteins by hijacking the natural Ubiquitin Proteasome System (UPS) employing heterobifunctional molecules called Proteolysis Targeting Chimeras or PROTACs.
These compounds have demonstrated the ability to drive…
THE UNIVERSITY OF EDINBURGH
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