CORDIS Project
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This project aims to enhance plant disease resistance by engineering synthetic helper proteins that improve the function of immune receptors in Solanaceae plants. By understanding the interactions between these proteins and pathogens, the project seeks to develop crops that can better withstand various diseases.
To resist pathogen colonisation, plants have evolved a number of complex defense mechanisms that are activated upon recognition of pathogen-secreted molecules.
These include cell surface or intracellular immune receptors, through either direct or indirect binding.
Nucleotide-binding leucine rich repeat proteins (NB-LRRs or NLR) make up the largest family of intracellular immune receptors.
Some of these NLR proteins were shown to function in pairs, with “sensors” mediating pathogen recognition an…
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