CORDIS Project
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This project investigates the dysfunction of T cells in chronic lymphocytic leukemia (CLL) and explores how to enhance the effectiveness of chimeric antigen receptor T cell therapy. By improving mitochondrial fitness in T cells, it aims to develop more effective treatments for CLL.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world.
Novel targeted drugs are effective, but not curative.
Moreover, prolonged use is associated with development of resistance, toxicity, and high economic cost.
Allogeneic stem cell transplantation, which evokes a T cell mediated response, is potentially curative yet is associated with high graft-vs-host-related mortality.
Therefore, an autologous T cell-based approach, e.g. chimeric antigen receptor T cells (CAR-T…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United States, Philadelphia
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United States, CLEVELAND
Type: Research institute
Activity type: Research Organisations
SME: No
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