CORDIS Project
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This project investigates how environmental factors at birth influence immune system development in newborns. By studying 1000 children over their first 1000 days, it aims to understand the impact of early exposures on long-term immune health and disease susceptibility.
Immune systems are highly variable, but the sources of this variation are poorly understood.
Genetic variation only explains a minor fraction of this, and we are unable to accurately predict the risk of immune mediated disease or severe infection in any given individual. I recently found that immune cells and proteins in healthy twins vary because of non-heritable influences (infections, vaccines, microbiota etc.), with only minor influences from heritable factors (Brodin, et al, Cell 2015).
Whe…
KAROLINSKA INSTITUTET
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