CORDIS Project
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This project investigates the entry mechanisms of hemorrhagic fever viruses into human cells, focusing on the Ebola and Lassa viruses. By employing advanced genetic techniques, it aims to identify host factors that facilitate viral entry and uncover potential antiviral targets.
Hemorrhagic fever viruses are serious human threats for which we don’t have adequate treatments available, which is painfully highlighted by the current Ebola virus outbreak in Western Africa.
These viruses are obligatory intracellular parasites that make use of the host machinery at every phase of their infection cycle.
Virus attachment and entry are the initial steps, which requires engagement of a viral glycoprotein with a cell surface receptor.
This interaction then triggers internalization…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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