CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates how DNA damage in neural progenitor cells during rapid division contributes to genetic diversity and potential neurodevelopmental disorders. It aims to understand the mechanisms behind DNA break clusters and their implications for brain cancer and psychiatric conditions using advanced genetic…
Neural progenitor cells undergo tens of thousands of cell divisions to generate the 80 billion neurons in a human brain.
In neural progenitor cells, replication stress can lead to recurrent DNA break clusters (RDCs).
Joining of two RDC breaks may introduce somatic genomic diversity.
On the other hand, unbalanced genomic mosaicism in neural progenitor cells may lead to brain cancer and neuropsychiatric disorders.
This proposal will test whether cell-autonomous DNA lesions that accumulate during r…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
