CORDIS Project
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This project investigates the signals and neurons connecting the nervous and digestive systems in fruit flies to understand their role in regulating metabolism and appetite. By exploring these mechanisms, the research aims to provide insights relevant to conditions like diabetes and obesity.
The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but studies aimed at identifying the signals involved are faced with daunting neuroanatomical complexity: there are as many as 500 million neurons in the human gut.
Drosophila should provide a simple and genetically amenable alternative, but both its autonomic nervous system and the signalling significance of its digestive tract have remained largely unexplored.
My research programme will characterize the signa…
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