CORDIS Project
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This project focuses on understanding the role of the BRCA2 protein in DNA repair mechanisms, particularly in relation to breast and ovarian cancer. It aims to characterize the interactions between BRCA2 and its partners to uncover the molecular basis of DNA repair.
Our genetic material is constantly exposed to mutagenic factors. DNA double-strand breaks (DSBs) represent one of the most dangerous forms of DNA damage and cells utilise two major pathways for their repair: error-prone non-homologous end-joining (NHEJ) and error-free homologous recombination (HR).
The breast cancer susceptibility protein BRCA2 is a central player in HR that cooperates with its partner PALB2 in promoting the recruitment of RAD51 recombinase to the site of DNA damage. BRCA2 funct…
CANCER RESEARCH UK LBG
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