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This research focuses on the role of RAD51 and BRCA2 in DNA repair through homologous recombination. It aims to understand how these proteins interact to facilitate DNA strand exchange, which is crucial for maintaining genomic stability.
Homologous recombination (HR) is an essential DNA repair mechanism and defects in different HR factors are linked with disease and cancer pre-disposition.
The RAD51 recombinase plays a central role in HR, forming nucleoprotein filaments at sites of DNA damage and promoting homologous pairing and DNA strand exchange. RAD51 filament formation is mediated by the BRCA2 tumour suppressor, mutations in which lead to a high incidence of developing breast cancer. BRCA2 interacts with other HR factors, s…
THE FRANCIS CRICK INSTITUTE LIMITED
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