CORDIS Project
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This project investigates how mutations in breast cancer genes BRCA1 and BRCA2 affect cancer stem cells and their response to therapies. It aims to understand the mechanisms of tumor resistance and the dynamics of cancer cell populations using advanced sequencing techniques.
Heterozygous germ line mutations in the breast cancer susceptibility genes (BRCA) 1 or 2 predispose carriers to breast, ovarian, pancreatic and prostate cancers.
Significant evidence has accumulated in recent years on vulnerabilities specific to BRCA1/2-deficient tumours, leading to the development of personalized therapies, such as poly-ADP ribose polymerase (PARP) inhibitors.
However, tumours develop resistance to these therapies, with tumour heterogeneity and enrichment in cancer stem cell (C…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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