CORDIS Project
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This project investigates how immune cells migrate through epithelial barriers, focusing on the role of junctional proteins and mechanical properties of cell connections. Using Drosophila as a model, it aims to understand the changes in cell adhesion and integrity during this process, which has implications for inflamm…
The ability of cells to invade underlies many pathological conditions such as metastasis and inflammation.
Invasion requires coordination of changes in the biology of the invading cell coupled with changes in the adhesive behavior and integrity of the penetrated barrier.
This proposed project aims to understand the modulation of epithelial integrity during immune cell transmigration.
Recent work has shown that Drosophila hemocytes invade through an epithelial barrier during embryonic development…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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