CORDIS Project
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This project aims to enhance a virus that targets tumors by modifying the tumor environment to stimulate an immune response. It involves using a chemotherapy drug to alter immune cell populations and genetically engineering an oncolytic adenovirus to improve its cancer-fighting capabilities.
The aim of this project is to enhance the efficacy of a tumour killing virus and break tolerance within the tumour to induce an immune response against the primary tumour and metastatic deposits.
The proposed strategy requires three steps.
First, the tumour immunological microenvironment needs to be reset as tumours utilize a variety of mechanisms to escape host immune system.
Here, we propose to use the chemotherapeutic agent cyclophosphamide to temporally deplete suppressor T cells and recruit…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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