CORDIS Project
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This project explores the role of specific receptors in pancreatic islets to develop new treatments for Type 2 diabetes. It focuses on understanding how certain receptors influence insulin secretion and beta-cell function, aiming to identify safer therapeutic targets with fewer side effects.
This Fellowship combines the expertise of the host group in the expression and function of islet G protein-coupled receptors (GPCRs) with the Fellow’s previous experience in identifying the role of retinoic acid and neurotrophin receptors in islet function. GPCRs are the targets of up to 50% of all prescription drugs and Byetta, a GLP-1 receptor activator used to treat Type 2 diabetes (T2D), provides proof of concept that ligands targeting islet GPCRs may be developed for T2D therapies.
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