CORDIS Project
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This project investigates how cells manage damaged chromosomes during cell division, focusing on the role of specific proteins in the segregation of acentric chromatids. Using Drosophila larvae, the research aims to uncover mechanisms that prevent aneuploidy, which is linked to cancer development.
The mechanisms that safeguard cells against aneuploidy are of great interest as aneuploidy contributes to tumorigenesis.
To gain insight into these mechanisms, we studied the behavior of cells entering mitosis with damaged chromosomes.
We used the endonuclease I-CreI to generate acentric chromosomes in Drosophila larvae.
While I-CreI expression produces acentric chromosomes in the majority of neuronal stem cells, remarkably, it has no effect on adult survival.
Our live studies reveal that acentr…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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