CORDIS Project
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This project focuses on developing selective small molecules to study the function of Bromo and Extra-Terminal proteins, which are crucial for gene regulation. By enhancing the selectivity of these molecules, the research aims to better understand individual protein roles in cellular processes.
Small molecules can be used to probe for biological function of individual proteins.
Achieving high selectivity with small molecules against structurally similar paralogues is a challenging task that makes it difficult to characterize function of individual member in the same protein family or individual domain in protein containing multiple target domains.
The Bromo and Extra-Terminal (BET) proteins play important roles in transcriptional regulation by controlling networks of genes involved in…
UNIVERSITY OF DUNDEE
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