CORDIS Project
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This research explores the role of butyrophilin-like molecules in immune surveillance, particularly in the skin and gut. By studying their interactions with immune cells, the project aims to uncover their potential in regulating inflammation and cancer in these tissues.
The butyrophilin-like (Btnl) molecules share similarities with the B7 family of costimulatory molecules for T cells, yet no functions are known.
They are encoded in the major-histocompatibility complex (MHC) locus, a region of the genome known to be highly relevant in many diseases.
Recently, Professor Hayday's lab identified a novel immunoglobulin-related molecule, Skint1, which appears to be a selection determinant for skin gamma delta T cells.
Furthermore, in the absence of Skint1 and normal…
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