CORDIS Project
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This project investigates the role of Biliverdin reductase-A in insulin signaling and its potential link to Alzheimer's disease. By studying a mouse model, it aims to understand how age-related changes in this enzyme affect insulin resistance and cognitive function.
Alzheimer disease (AD) is the most common form of dementia among the elderly, whose care in Europe demands an amount of financial resources which is rising dramatically making AD a financial problem.
Delaying AD onset by 5 years would decrease its prevalence by 50% with an enormous impact on the financial resources involved in AD care.
Hence, it is necessary to understand the mechanisms related to the earlier phases before the symptoms onset.
Insulin resistance is associated with a higher risk t…
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
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