CORDIS Project
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This project aims to develop new methods for studying the dynamics of large proteins, specifically those weighing 80-100 kDa, using advanced solid-state nuclear magnetic resonance techniques. By expanding the molecular weight range accessible for analysis, it seeks to enhance our understanding of protein behavior and i…
My objective is to establish methodology expanding the detailed characterization and exploitation of backbone dynamics in complex proteins up to 80-100 kDa monomer molecular weight.
Experimental elucidation of protein motion is imperative for fundamental understanding of enzymatic and regulatory features.
However, with a limit of regularly around 40-50 kDa maximum total mass, the more complex targets of current scientific interest usually evade solution NMR backbone resonance assignment and rema…
TECHNISCHE UNIVERSITAT DORTMUND
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