CORDIS Project
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The project investigates the role of synaptic scaffolding molecules in organizing neurotransmitter receptors at synapses. Using C. elegans as a model, it aims to uncover the genetic and molecular mechanisms that regulate synaptic structure and function.
Synaptic scaffolding molecules control the localization and the abundance of neurotransmitter receptors at the synapse, a key parameter to shape synaptic transfer function.
Most characterized synaptic scaffolds are intracellular, yet a growing number of secreted proteins appear to organize the synapse from the outside of the cell.
We recently demonstrated in C. elegans that an evolutionarily conserved protein secreted by motoneurons specifies the excitatory versus inhibitory identity of the post…
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