CORDIS Project
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This project explores how stem cells maintain their ability to self-renew and differentiate, focusing on the role of the transcription factor Nanog. By studying the mechanisms of heterogeneity in stem cell populations, the research aims to enhance understanding of stem cell behavior and its implications for regenerativ…
How stem cell populations balance the opposing forces of self-renewal and differentiation to maintain a functional population is a question that strikes at the heart of what it means to be a stem cell.
Undifferentiated embryonic stem cell (ESC) identity is maintained by transcription factors (TFs) of the pluripotency gene regulatory network (PGRN) centred on the TFs Oct4, Sox2 and Nanog. ESCs with high levels of Nanog self-renew efficiently while ESCs with low Nanog levels are prone to different…
THE UNIVERSITY OF EDINBURGH
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