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CADABRE is developing advanced human antibody repertoires to improve therapeutic candidates by enhancing their stability and effectiveness. The project employs innovative design and AI techniques to create diverse antibodies suitable for drug development.
Synthetic human antibody repertoires are an important source of therapeutics; however, antibodies often exhibit undesirable developability liabilities, such as low stability, solubility, and polyreactivity, that limit their potential as drug candidates. CADABRE will design next-generation repertoires comprising billions of diverse human antibodies that exhibit excellent developability properties, with the following aims:1.
Repertoire design:
We will use our newly developed combinatorial Rosetta…
WEIZMANN INSTITUTE OF SCIENCE
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