CORDIS Project
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This project investigates the role of the Aire protein in promoting immune tolerance by regulating the expression of self-antigens in thymic epithelial cells. It aims to uncover post-transcriptional mechanisms that enhance self-antigen levels, potentially leading to new therapeutic targets for autoimmune diseases.
Immune tolerance is key to the maintenance of the integrity of organisms against foreign invaders with respect to self-constituents.
Deregulation of this mechanism promotes the occurrence of life-threatening autoimmune diseases that affect 5-10% of the general population.
Previously, the transcriptional activator (Aire) was shown to play a key role in immune tolerance.
Indeed, Aire induces medullary epithelial cells in the thymus (MECs) to synthesize and present a large repertoire of peripheral…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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