CORDIS Project
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This project focuses on targeting cancer-associated fibroblasts using a novel drug delivery system to improve cancer treatment. By selectively depleting these fibroblasts, the research aims to understand their role in tumor growth and drug response, potentially leading to new therapeutic strategies.
Cancer is a major health burden affecting 12-million people each year world-wide.
Tumor growth is not only determined by tumor cell malignancy but also by the tumor microenvironment.
Cancer-associated fibroblasts (CAF) are key cell type in the tumor microenvironment influencing tumor initiation, angiogenesis, metastasis and tumor drug response. CAF strongly express platelet-derived growth factor receptors (PDGFR).
The applicant has recently developed a novel drug delivery technology to target CA…
KAROLINSKA INSTITUTET
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