CORDIS Project
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This project investigates how the bacterium Shigella is captured by host cell structures known as septin cages, which prevent its replication. By identifying the factors involved in this process, the research aims to uncover new insights into infection biology and potential treatments for shigellosis.
Shigella is a Gram-negative bacterial pathogen and causative agent of bacillary dysentery (also called shigellosis).
Shigella kills ∼164 thousand people per year and is recognised by the WHO as a priority pathogen due to the emergence of antibiotic resistant strains.
In the laboratory, Shigella is an important model organism used to study cellular microbiology and host response to infection.This proposal will innovate approaches to discover factors underlying the entrapment of Shigella in “septi…
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
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