CORDIS Project
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This research focuses on understanding how chromosome segregation is maintained in pluripotent stem cells. It aims to identify the mechanisms affecting genomic stability during the reprogramming of somatic cells into induced pluripotent stem cells.
Maintaining a stable karyotype is essential for the use of pluripotent stem cells (PSCs) in regenerative medicine and translational and basic research.
Although around 10-30% of PSC lines present karyotypic abnormalities, the molecular mechanisms underlying this genomic instability are largely unknown.
Centromeres, the chromosomal loci that drive chromosome segregation are central to mitotic fidelity.
Maintenance of centromeres in somatic cells is tightly cell cycle coupled, as centromeric chrom…
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