CORDIS Project
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This project explores the connections between the skull and brain to understand neurodegenerative diseases. By studying immune cell trafficking and potential biomarkers, it aims to develop new diagnostic and therapeutic strategies for conditions like stroke and dementia.
Neurodegenerative diseases (NDs) are labeled as the epidemic of the 21st century.
The inflammation of the brain is a common pathology observed in many NDs.
Here I aim to exploit our discovery of skull – meninges connections (SMCs) mediating immune cell trafficking into the brain to ease this healthcare burden.
Using tissue clearing methods, we found that the skull (calvaria) bone marrow is directly connected to the brain meninges, a discovery that was also shown by an independent group around th…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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