CORDIS Project
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This project investigates the role of the aryl hydrocarbon receptor (AHR) in cancer, focusing on its complex activation and effects on tumor progression and immunity. By developing a pan-tissue AHR signature, the project aims to understand how AHR activation varies across different cancers and to identify potential the…
The aryl hydrocarbon receptor (AHR) is a critical regulator of tumor progression by modulating both tumor cell intrinsic malignant properties as well as anti-tumor immunity.
However, depending on the context, the AHR can exert either tumor-promoting or tumor-suppressive effects, thus limiting its potential as a drug target.
To exploit the AHR for cancer therapy a comprehensive understanding of its activation and biological outcomes is necessary.
The opposing effects of the AHR in cancer likely s…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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