CORDIS Project
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This project explores the biological mysteries of aneuploidy in cancer, focusing on how chromosome imbalances affect tumor evolution and identify specific vulnerabilities in cancer cells. By utilizing advanced genomic and functional methods, it aims to uncover potential therapeutic targets for treating aneuploid cancer…
Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a distinct feature of cancer.
Recent years have seen conceptual, methodological and technical advances in the field of cancer aneuploidy research, but we are just beginning to scratch the surface of the underlying biology, and the potential vulnerabilities of aneuploid cancer cells remain under-explored.
Cancer aneuploidy is therefore a biological enigma and a missed opportunity for cancer therapy.Identifying the “Achilles he…
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