CORDIS Project
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This project focuses on developing advanced technologies to analyze tumor subclones at a single-cell level, aiming to improve understanding of drug resistance in cancers like Non-Small Cell Lung Cancer and Glioblastoma. It combines techniques for capturing RNA and DNA enhancers, enhancing the detection of genetic diver…
To comprehend the characteristics, phylogenetic relationships, and drug resistance of tumor subclones, measurements must be performed at single-cell or single-clone resolution.
Aims 1 and 2 aim to create cost-effective and reliable single-cell drop technologies for capturing full-length RNA (Scfl-RNA-Seq) and enhancers at the DNA level (ChromOpen).
It is noteworthy that Scfl-RNA-Seq also captures non-coding and non-polyadenylated RNAs besides coding mRNA.
ChromOpen also offers better capturing o…
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